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This issue discusses the hot-button issue of racial disparities in respiratory health. Topics covered include an in-depth look at asthma in the urban environment and among Latinos and African Americans. Lung cancer is also discussed as it presents in US minority populations. Sarcoidosis, COPD, and sickle cell lung disease are also reviewed. The issue tackles questions about outcome disparities, barriers to lung transplantation, and HIV in minorities. It concludes with an examination of how these disparities might be eliminated.