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This Witness Seminar discusses the scientific origins of gene mapping and emergence of the Human Gene Mapping Workshops (HGMW). From HGM1 in Yale (1973) to HGM11 in London (1991), key scientists, based principally in the UK, share memories of participating in these workshops and reflect on the historical importance of the HGMW in contemporary biomedicine. Topics include the influence of somatic cell genetics; role of non-human gene mapping; advent of DNA-based techniques; the culture of collaboration in the gene mapping community; nomenclature challenges; clinical applications; the informatics revolution; the origins of the Human Genome Project and advent of sequencing technologies. Throughout, tribute is paid to the contributions of international colleagues to gene mapping. The seminar was chaired by Professor Peter Harper, and the volume is introduced by Professor Peter Goodfellow.
